1. Clipping is a handy way to collect important slides you want to go back to later. Looks like youve clipped this slide to already. 1. 1982. The copyright of the text is held by Trustees of Boston University. A common use of the term area under the curve (AUC) is found in pharmacokinetic literature. total amount of drug eliminated by the body may be assessed by adding up PHARMACOKINETICS: BASIC CONSIDERATION & PHARMACOKINETIC MODELS, Pharmacokinetics / Biopharmaceutics - One compartment model IV bolus, Non linear pharmacokinetics and different volumes of distribution, Pharmacokinetics / Biopharmaceutics - Multi compartment IV bolus, Clinical Pharmacokinetics-I [half life, order of kinetics, steady state], A seminar on one & two compartment open model extra vascular administration, A.U.C. . This parameter is calculated using the following equation: I described previously how to calculate AUC 0-t. Also, AUC is referenced when talking about elimination. As we cannot get the assays to go to infinity, we have to extrapolate to infinity. Pharmacokinetics -Auc - area under curve. Simply put, PK describes what the body does to the drug, and PD describes what the drug does to the body. Calculating Area Under the Curve (AUC) Parameters. $$AUC = \color{cyan}{AUC0}-\color{cyan}2 + \color{pink}{AUC2}-\color{pink}4+\color{purple}{AUC4}-\color{purple}{6}+\\\color{yellow}{AUC6}-\color{yellow}{8}+\color{green}{AUC8}-\color{green}{10}+\color{HotPink}{AUC10}-\color{HotPink}{12}+\\\color{RoyalBlue}{AUC last}-\color{RoyalBlue}{infinity}$$. When CL vanco or Vd are unknown, population estimates are used based on published literature. Therefore, in such situations, the body exposure to the drug and the area under the concentration-time curve are smaller. Oral administration. 2nd ed. It represents the area under the plasma concentration curve, also called the plasma concentration-time profile. In practice, the drug concentration is measured at certain discrete points in time and the trapezoidal rule is used to estimate AUC.Contents1 Interpretation and . The clearance calculated is relatively independent on the shape of the concentration-time profile. This area under the curve is dependant on the rate of elimination of the drug from the body and the dose administered. After an iv bolus injection, the AUC can be calculated by the following equation: Trapezoidal rule: It consists in dividing the plasma reasons can be found ! The area of a trapezoid can be calculated using a variety of rules. In the field of pharmacokinetics, the area under the curve (AUC) is the definite integral of the concentration of a drug in blood plasma as a function of time (this can be done using liquid chromatography-mass spectrometry).In practice, the drug concentration is measured at certain discrete points in time and the trapezoidal rule is used to estimate AUC. When performing non-compartmental analysis, the area under the concentration-time curve (AUC) is calculated to determine the total drug exposure over a period of time. Gibaldi M, Perrier D. Pharmacokinetics. In biomedical studies, the computation of Area Under the Curve (AUC) is a convenient way to combine multiple readings, such as some metabolic values (glucose and insulin) or blood (serum or plasma) concentration within a specific time interval, into a single index in drug toxicology and pharmacokinetics. One way to quantify how well the logistic regression model does at classifying data is to calculate AUC, which stands for "area under curve." The closer the AUC is to 1, the better the model. In the field of pharmacokinetics, the area under the curve (AUC) is the definite integral of the concentration of a drug in blood plasma as a function of time (this can be done using liquid chromatography-mass spectrometry).In practice, the drug concentration is measured at certain discrete points in time and the trapezoidal rule is used to estimate AUC. Knowing the bioavailability and the dose, the clearance of the drug may be calculated by dividing the dose absorbed by the AUC. This method gives precious information on the pharmacokinetic behavior of a drug on trial. Method development and validation of simultaneous estimation of paracetamol & Expt. Another use is in the therapeutic drug monitoring of drugs with a narrow therapeutic index. The area under the concentration vs time curve is a useful description of exposure of drug following administration. High Resolution Mass Spectrometry (HR-MS), Drug-Drug Interaction (DDI) Studies in Clinical Pharmacology, Pharmacokinetic / Toxicokinetic / Pharmacodynamics (PK / PD/ TK) Analysis, Analytical and Materials Science Solutions, Solid Form Screening and Selection Centre of Excellence, Impurity and Contamination Centre of Excellence, Bioanalytical services for biopharmaceuticals, Pharmacokinetics: Area under the curve calculations. The following step-by-step example shows how to calculate AUC for a logistic regression model in R. Step 1: Load the Data In the field of pharmacokinetics, the area under the curve (AUC) is the definite integral of a curve that describes the variation of a drug concentration in blood plasma as a function of time (this can be done using liquid chromatography-mass spectrometry).In practice, the drug concentration is measured at certain discrete points in time and the trapezoidal rule is used to estimate AUC. 2. from movie A BEAUTIFUL MIND. Partial AUC (\( {\mathrm{pAUC}}_{t_0\hbox{--} {t}_p} \)) is defined as the area under the plasma concentration (C t) versus time profile over two specified time points (Eq. What is known and objective: The revised vancomycin monitoring guidelines recommend targeting an area under the curve (AUC) of 400-600 mg*hr/L for serious methicillin-resistant Staphylococcus aureus (MRSA) infections. All rights reserved. The standard method for calculating AUC parameters is the linear-up/log-down trapezoidal method. AUMC can be mathematically expressed as: (6.6) Knowledge about AUC and AUMC allows further calculation and analysis of drug characteristics. The total AUC or AUC 0- is the area under the curve from time 0 extrapolated to infinite time. AUC, area under the curve; C0, trough level. Compute the area of all trapezoids and sum them to give the AUC up to the last sample drawn. Steady state concept. I am a teacher of Mathematics. See Also. The AUC is directly proportional to the dose when the drug follows linear kinetics. In type 1 diabetes research, a concept of mean AUC is also used. Two sets of hypothetical . Free access to premium services like Tuneln, Mubi and more. Then, approximating the area of each strip by the area of the trapezium formed when the upper end is replaced by a chord. ROC Curve and AUC. They helped me a lot once. Nonlinear pharmacokinetics. https://en.wikipedia.org/w/index.php?title=Area_under_the_curve_(pharmacokinetics)&oldid=1104795171, Creative Commons Attribution-ShareAlike License 3.0, This page was last edited on 16 August 2022, at 23:27. 13985205. Weve updated our privacy policy so that we are compliant with changing global privacy regulations and to provide you with insight into the limited ways in which we use your data. #areaunderthecurve #auc #biopharmaceutics #pharmacokinetics #pharmacyd #pharmacydbyasimArea under the curve or AUC, represents the total integrated area unde. It is derived from drug concentration and time so it gives a . Area under curve (AUC) is an indicator of the total amount of the drug absorbed into the systemic circulation and it is directly proportional to the dose adm. reaches the systemic circulation. The under-the-receiver operating characteristic curve (AUC) was utilised to determine the accuracy of a good forecast; for example, if AUC is ranged between 0.5 and 1, where 0.5 implies a poor estimate, while an excellent forecast is when AUC approaches or is equal to 1. Module 6-Area Under The Curve. 2011. Structure. zero (time of the administration of the drug) to infinite time. It is calculated by ranking predicted probabilities . Below is the formula to calculate the area of a trapezoid. Area under the curve AUC is a useful approach for integrating serial assessments of a patient's outcome over the duration of a study. 1. The area under the plasma drug concentration-time curve (AUC) reflects the actual body exposure to drug after administration of a dose of the drug and is expressed in mg*h/L. It is the region under a plotted line in a graph of medicine concentration in blood plasma over time. 2019; 39(4):433-442; Buelga et al. 41 While area AUC is a fundamental concept in pharmacokinetics, until recently, its use in clinical trials has been largely neglected and only used in a few therapeutic areas. Sort. and the following few pharmacokinetic para-meters can be defined: - peak concentrations (C max) - peak time (T max) - terminal half-life (t2) - area under the curve (AUC) When urines are also sampled, the drug amounts excreted unchanged or the percent-age of the dose excreted in urines should al-so be computed. Background: Currently, the achievement of the target area under the curve (AUC)/minimum inhibitory concentration ratio during the first 24 - 48 h of treatment is associated with reduced 30-day mortality and greater microbiological eradication in patients with methicillin-resistant Staphylococcus aureus bacteremia. Suggest. You can read the details below. AUC, area under the curve; AUC/MIC, ratio of AUC to MIC (time and concentration-dependent antibiotics); Cmax, peak . That is, the higher the clearance, the less time the drug spends in the systemic circulation and the faster the decline in the plasma drug concentration. We have an Answer from Expert View Expert Answer This Among seven machine learning algorithms, Support Vector Machine (SVM) have better performance in differentiating patients with violence from those without violence, with its balanced accuracy and area under curve (AUC) reaching 0.8231 and 0.841, respectively. The information is useful for determining dosing and for identifying potential drug interactions. INTRODUCTION. The area is conveniently determined by the "trapezoidal rule": the data points are connected by straight line segments, perpendiculars are erected from the abscissa to each data . This is often measured by quantifying the "AUC". administration of a dose of the drug and is expressed in mg*h/L. AUMC is the total area under the first moment curve. from the dose divided by the AUC, reflects the drugs clearance that In practice, the drug concentration is measured at certain discrete . Introduction to pharmacokinetics; IV administration Thelinear trapezoidal linear interpolationrule will draw a linear line between each pair of data points: There are additional rules, and these are specified in our study plans. Like www.HelpWriting.net ? Blockchain + AI + Crypto Economics Are We Creating a Code Tsunami? Activate your 30 day free trialto unlock unlimited reading. Conversion from vancomycin trough concentration-guided dosing to area under the curve-guided dosing using two sample measurements in adults: implementation at an academic medical center. Interpretation and usefulness of AUC values. Sort. It is frequently used in clinical pharmacology where the AUC from serum levels . AI and Machine Learning Demystified by Carol Smith at Midwest UX 2017, Pew Research Center's Internet & American Life Project, Harry Surden - Artificial Intelligence and Law Overview, No public clipboards found for this slide. The area under the curve demonstrates the time for drugs to be absorbed in the blood stream, the maximum concentration in blood at its peak and the lowest drug concentration in blood over time. AUC 0-12h). In many pharmacokinetic textbooks, a single Vd (such as 0.7 L/kg) or CL vanco (such as 70% of creatinine clearance) are recommended. In the field of pharmacokinetics, the area under the curve (AUC) is the definite integral of the concentration of a drug in blood plasma as a function of time (this can be done using liquid chromatographymass spectrometry[1]). Population pharmacokinetic analysis of vancomycin in patients with hematological malignancies. IV administration. AUC. It is used as a cumulative measurement of drug effect in pharmacokinetics and as a means to compare peaks in chromatography. Instant access to millions of ebooks, audiobooks, magazines, podcasts and more. Again, the relative AUCs are used to make this comparison and relative doses are used to normalize the calculation. APIdays Paris 2019 - Innovation @ scale, APIs as Digital Factories' New Machi Mammalian Brain Chemistry Explains Everything. D/ClT, where F is the bioavailability of the drug. Activate your 30 day free trialto continue reading. Area Under The Curve AUC. 4th ed. In the field of pharmacokinetics, the area under the curve (AUC) is the definite integral of a curve that describes the variation of a drug concentration in blood plasma as a function of time (this can be done using liquid chromatography-mass spectrometry). Bioavailability is less or equal to 100% for any other route of administration. Pharmacodynamics defines the relationship between plasma and tissue drug and/or metabolite concentrations, time, and therapeutic response. Notice that the drug con- Basic Intravenous Therapy 2: Pharmacology, Rational Therapy, Pharmacodynamics Netaji College of Elementary Teacher Education, Kanchikacherla, Modelling & comparison of dissolution profiles by Paulo Costa, Introduction to clinical pharmacokinetics, Irresistible content for immovable prospects, How To Build Amazing Products Through Customer Feedback. In the field of pharmacokinetics, the area under the curve (AUC) is the definite integral of the concentration of a drug in blood plasma as a function of time (this can be done using liquid chromatography-mass spectrometry).In practice, the drug concentration is measured at certain discrete points in time and the trapezoidal rule is used to estimate AUC. Compare LR (+) equal to one [1] in the Fagan diagram, Figure 15. AUC=P (Event>=Non-Event) AUC = U 1 / (n 1 * n 2 ) Here U 1 = R 1 - (n 1 * (n 1 + 1) / 2) where U1 is the Mann Whitney U statistic and R1 is the sum of the ranks of predicted probability of actual event. The extrapolation of AUC to infinity requires several . In the field of pharmacokinetics, the area under the curve (AUC) is the definite integral of the concentration of a drug in blood plasma as a function of time (this can be done using liquid chromatography-mass spectrometry). Absolute bioavailability refers to the bioavailability of drug when administered via a non-intravenous (non-IV) dosage form (i.e. Area Under The Curve Abbreviation in Pharmacokinetics . AUC is approximated by a series of trapezoids. The AUC is then calculated for the area under time-C-Peptide curve over 2 hour (AUC 0-2hr) or 4 hours (AUC 0-4hr) (see Greenbaum at al " Mixed-Meal Tolerance Test Versus Glucagon Stimulation Test for the Assessment of -Cell Function in Therapeutic Trials in Type 1 Diabetes"). It is used as a cumulative measurement of drug effect in pharmacokinetics and as a means to compare peaks in chromatography. Abstract. AUC becomes useful for knowing the average concentration over a time interval, AUC/t. Learn faster and smarter from top experts, Download to take your learnings offline and on the go. Area under the plasma concentration time curve (AUC) The area under the plasma (serum, or blood) concentration versus time curve (AUC) has an number of important uses in toxicology, biopharmaceutics and pharmacokinetics. LogAUC, AUC. Pharmacokinetics -Auc - area under curve. An ROC curve measures the performance of a classification model by plotting the rate of true positives against false positives. Click here to review the details. bioavailability. a fast overview of area under curve and its determination for iv bolus unchanged drug in plasma in biopharmaceutics and pharmacokinetics; also in pharmacolo. A model that has an AUC of 1 is able to perfectly classify observations into classes while a model that has an AUC of 0.5 does no better than a model that performs random guessing. of the studied drug is not known. concentration-time profile into several trapezoids and calculating the of elimination of the drug from the body and the dose administered. I teach for JEE Advanced, JEE Mains, CBSE and all other engineering entrance examinations. oral tablet, suppository, subcutaneous, etc.) Relationship between area under curve (AUC) values in the range of the minimum and maximum false positive rates (FPRs) from the eight observers and true positive rates from eight observers (TPR obs s) obtained using Protocol 3 (c). The list short forms for Area Under The Curve abbreviation in Pharmacokinetics. !" - quote from movie A BEAUTIFUL MIND. This study aimed to determine the AUC and pharmacokinetic parameters on the . , Healthcare. Determination of absorption and elimination rates on base of compartment model. Typically, the area is calculated starting from the time the medicine is administered until the time when the concentration in plasma is insignificant. ROC is short for receiver operating characteristic. This page summarises the calculations and terminology that may be encountered. Thus we only have to calculate AUC t- to complete the equation listed above. The equation is a regression equation; the correlation coefficient was calculated using simple regression analysis Dr Nirav , MD Pharmacology , Jamnagar 6-Area Under The Curve. Sandwich Laboratory: Discovery Park, Ramsgate Rd, Sandwich CT13 9FF, Registered Office: Drug Development Solutions Ltd, Newmarket Rd, Fordham, Ely CB7 5WW.Registered in England No. This fraction is normalized by multiplying by each dosage form's respective dose.[3]. By integrating over time rather than looking at individual concentration measurements, a more accurate estimate of the overall exposure to the drug . b is the base length of the other side. The area under each of the trapezoids are summed (shaded area above) to give an AUC: Where a logarithmic trapezoidal rule is employed for a trapezoid, the formula is: AUCt1-t2= (t2-t1)*((Cp1-Cp2)/ln(Cp1/Cp2)), where Cptis the plasma concentration at the last quantifiable time point and Kel is the terminal elimination rate constant. Now customize the name of a clipboard to store your clips. In practice, the drug concentration is measured at certain discrete points in time and the trapezoidal rule is used to estimate AUC. Bioavailability can be measured in terms of "absolute bioavailability" or "relative bioavailability". Mean residence time (MRT) which is the average time the drug stays . Using trapezoidal rule to approximate the area under a curve first involves dividing the area into a number of strips of equal width. The area under the plasma drug concentration-time The area under the curve is an integrated measurement of a measurable effect or phenomenon. The AUC (from zero to infinity) represents the total drug exposure across time. RMI Pharmacokinetics +1 760 602 0000 +1 805 300 1053 . In the field of pharmacokinetics, the Area Under the Curve (AUC) has a specific meaning. AUC (area-under-the-curve): This is the overall amount of drug in the bloodstream after a dose. This study was designed to assess whether the application of our . Pharmacother. We've encountered a problem, please try again. Did u try to use external powers for studying? Area Under tThe Curve. AUC t1-t2 = (t 2-t 1)*((C p1-C p2)/ln(C p1 /C p2 )) AUC 0-last describes the area under the curve up to the last quantifiable time-point (sometimes referred to as AUC 0-t) AUC 0-x describes the area under the curve limited to a specific time (e.g. For example, theLinear Log Trapezoidalrule will draw a linear line between pairs of data points that are prior to Cmax, and a logarithmic line between data points following Cmax. AUC, short for area under the ROC curve, is the probability that a classifier will rank a randomly chosen positive instance higher than a randomly . Tap here to review the details. compared with the bioavailability of the same drug administered intravenously (IV). An AUC can be measured by checking a peak and trough concentration at steady state; however, this requires obtaining an additional blood sample. Toxicology AUC can be used as a measure of drug exposure. Area under the curve (pharmacokinetics), regarding plasma drug concentration-time curves; Authentication Center in a GSM mobile phone network; United Self-Defense Forces of Colombia (Spanish: Autodefensas Unidas de Colombia), former Colombian paramilitary and drugs group; Drug pharmacokinetics in renal dysfunction. Purpose Docetaxel is metabolized by cytochrome P450 (CYP3A4) enzyme, and the area under the concentration-time curve (AUC) is correlated with neutropenia. The area under the curve is an integrated measurement of a measurable effect or phenomenon. Clinical Pharmacokinetics and Pharmacodynamics - Concepts and Applications. The AUC is directly proportional to the dose when the drug follows linear kinetics. In the field of pharmacokinetics, the area under the curve (AUC) is the definite integral of a curve that describes the variation of a drug concentration in blood plasma as a function of time (this can be done using liquid chromatography-mass spectrometry[1]). He holds a PhD in Pharmaceutical Sciences from the University of Michigan and has . In practice, the drug concentration is measured at certain discrete points in time and the trapezoidal rule is used to estimate AUC. AUC is a useful metric when trying to determine whether two formulations of the same dose (for example a capsule and a tablet) result in equal amounts of tissue or plasma exposure. Are you a visual learner interested in learning psychopharmacology? 13 Calculation of pharmacokinetic parameters from a given data, Excretion and kinetic of eliminatoin.. dr. kiran 15th feb 2021. Below is the formula that I can use (in the adjacent column) to calculate the area of a trapezoid in the chart for my dataset: Area Under the Curve (AUC) A measure of how much drug reaches a person's bloodstream in a given period of time after a dose is given. Dr. Teuscher has been involved in clinical pharmacology and pharmacometrics work since 2002. does not take into account thebioavailability of the drug. . Literature demonstrates that these population estimates vary widely in certain patient populations, such as . Bioanalytical data consists of a series of concentrations at various time points following dose administration. (), t 0 and t p are two time points of interest) (FDA 2010b)For example, to quantify an early exposure, a partial AUC can be defined as the AUC between the time of dosing to the median time of the maximum concentration of a . The SlideShare family just got bigger. Lappin, Graham; Rowland, Malcolm; Garner, R Colin (2006). Bridging the Gap Between Data Science & Engineer: Building High-Performance T How to Master Difficult Conversations at Work Leaders Guide, Be A Great Product Leader (Amplify, Oct 2019), Trillion Dollar Coach Book (Bill Campbell). Devlopment and validation of rp hplc method for simultaneous ex. $\begingroup$ Area under the curve is the integral of the curve where plasma concentration is plotted against time. The first moment curve is prepared when concentration x time is plotted versus time. A common use of the term "area under the curve" (AUC) is found in pharmacokinetic literature. AUC = Area under the concentration-time curve, C(0) = extrapolated plasma concentration at time0. AUC, area under the curve; C0, trough level. AUC(0-inf): AUC curve to infinite time. AUC 2 - Calculation of area under the plasma level versus time curve (AUC) a. . 41,42 As indicated in equation 1, the clearance is simply the ratio of the dose to the AUC, so that the higher the AUC for a given dose, the lower the clearance. To this end, systematic reviewing and meta-analysis were used in the current study as pharmaceutics informatics tools [15,25] in order to track the influence of delivering drugs utilizing nanoparticulate systems on the area under the curve (AUC) as an in vivo pharmacokinetic parameter and important indicator of the superior bioavailability of . Drug elimination. Download scientific diagram | Pharmacokinetic and pharmacodynamic parameters. Meng et al. The term bioequivalence is used when . revised and expanded. h is the height. The term relative bioavailability is used to compare two different extravascular routes of drug administration. curve (AUC) reflects the actual body exposure to drug after Where is the amount excreted in urine between time t 1 and t 2 and is the area under the curve for the same time interval . We developed a novel method for estimating the interpatient variability of CYP3A4 activity by the urinary metabolite of exogenous cortisol (6-beta-hydroxycortisol [6--OHF]). or integrating the amounts eliminated in each time interval, from time FIGURE 2.: Smoothed time profiles of the mean relative intraindividual variations of the metrics of interest, depending on the time between 2 instances (A) (censored at 5 y) and posttransplant period (censored at 15 y) (B) (continuous). ! - quote It is only in the mysterious The sum of these approximations gives the final numerical result of the area under the curve. All trademarks acknowledged. The . Alternative methods may be used for calculating AUC parameters, but justification for this change should be provided in the final clinical study report (CSR) or PK report. The In the field of pharmacokinetics, the area under the curve (AUC) is the definite integral in a plot of drug concentration in blood plasma vs. 80 relations. A xenobiotic can be potent but still have a large area under the curve, and vice versa. In pharmacokinetics, bioavailability generally refers to the fraction of drug that is absorbed systemically and is thus available to produce a biological effect. The term absolute bioavailability is used when the fraction of absorbed drug is related to its i.v. For example, gentamicin is an antibiotic that can be nephrotoxic (kidney damaging) and ototoxic (hearing damaging); measurement of gentamicin through concentrations in a patient's plasma and calculation of the AUC is used to guide the dosage of this drug. Enjoy access to millions of ebooks, audiobooks, magazines, and more from Scribd. By accepting, you agree to the updated privacy policy. (Area Under Curve) Dr Jayesh Vaghela, Two compartment open model sulekhappt.x.1, Seminar on pharmacokinetic parameters of two compartment open model, Pocket Guide: Pharmacokinetics Made Easy - sample, Pharmacokinetics of IV infusion, one-compartment open model. Area Under the Curve(AUC) and Area Under the first Moment Curve(AUMC) by linear trapezoidal method Description. AUC Dr Nirav , MD Pharmacology , Jamnagar "It is only in the mysterious equations of love that any logical reasons can be found ! The apparent clearance, resulting AUC 0-12h). Apparent clearance (CL): In some pharmacokinetic trials, the bioavailability AUC by adding the area of these trapezoids. equations of love that any logical This time may fall between available data points, in which case interpolation is used . AUC may refer to: Ab urbe condita or . There are different ways in which AUC may be calculated, and terminology may vary from one source or text to another. VAT No 415 6199 88. The amount eliminated by the body (mass) = clearance (volume/time) * AUC (mass*time/volume). Vancomycin Pharmacokinetic Models and Population Estimates. Area Under The Curve Abbreviation in Pharmacokinetics. Multiple compartment pharmacokinetics. In order to determine the respective AUCs, the serum concentration vs. time plots are typically gathered using C-14 labeled drugs and AMS (accelerated mass spectrometry).[2]. 2 ways to abbreviate Area Under The Curve in Pharmacokinetics: Pharmacokinetics. We've updated our privacy policy. It is of interest to know the area under the curve, i.e., the area defined by the plasma concentration curve at the top and the x-axis . In the field of pharmacokinetics, the area under the curve (AUC) is the definite integral of the concentration of a drug in blood plasma as a function of time (this can be done using liquid chromatography-mass spectrometry [1]).In practice, the drug concentration is measured at certain discrete points in time and the trapezoidal rule is used to estimate AUC. dbo: abstract. The shape under each pair of data points forms a trapezoid. Pharmacokinetics. Area under blood concentration-time curve from zero to infinity Area under the plasma metabolite concentration-time curve from zero to infinity AUC (0-t) Area under the plasma concentration-time curve from zero to the time of the last quantifiable concentration AUC ex Percent of AUC obtained by extrapolation AUC ss AUMC Area under the plasma . Hi, I am Ankush Gupta. In pharmacology, the area under the plot of plasma concentration of a drug versus time after dosage (called "area under the curve" or AUC) gives insight into the extent of exposure to a drug and its clearance rate from the body.
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